Job Title: Contract Scientist – Protein Optimization (Laboratory Support)
Location: Cambridge, MA
Assignment Type: Contract (1 year)
Schedule: Full-Time

Position Overview

A leading global biopharmaceutical organization is seeking a Contract Scientist to support its Protein Optimization team in Cambridge, MA. This laboratory-based role will focus on accelerating yeast display and molecular biology workflows through hands-on experimental support.

The ideal candidate will bring strong bench-level molecular biology experience and the ability to reliably execute established protocols while maintaining detailed documentation. This position is well-suited for a Research Associate to Associate Scientist-level professional who thrives in a collaborative, fast-paced research environment.

Key Responsibilities

• Perform routine, hands-on molecular biology workflows to support protein optimization and yeast display efforts

  
  

• Execute yeast transformations, colony picking, routine cell maintenance, and culturing

  
  

• Conduct plasmid preparation, PCR amplification, gel electrophoresis, and DNA purification

  
  

• Prepare DNA samples suitable for next-generation sequencing (NGS)

  
  

• Support cloning efforts including restriction digest, gel purification, combinatorial library design, and saturation mutagenesis

  
  

• Assist with DNA insert design and coordinate external synthesis as needed

  
  

• Operate flow cytometry analyzers and FACS sorters to support yeast display workflows

  
  

• Prepare yeast cultures for FACS sorting and extract DNA from selected populations

  
  

• Register DNA and protein sequences in internal systems for proper documentation and banking

  
  

• Maintain meticulous laboratory records and collaborate closely with cross-functional scientific teams

Required Qualifications

Education:

• B.S. in Molecular Biology, Biochemistry, Biophysics, Immunology, or a related field

Experience:

• At least 1 year of hands-on laboratory experience

  
  

• Strong molecular biology skills including cloning, transformation, plasmid prep, PCR, and sequence analysis

  
  

• Experience with sterile technique and cell culture

  
  

• Working knowledge of protein engineering methods

  
  

• Demonstrated ability to work effectively within a collaborative research team

  
  

• Strong written and verbal communication skills

Preferred Qualifications

• Industry experience in biotechnology or pharmaceutical settings

  
  

• Experience with yeast, mammalian, or phage display systems

  
  

• Hands-on experience preparing and handling samples for next-generation sequencing

  
  

• Experience operating flow cytometry analyzers and FACS sorters

  
  

• Basic understanding of antibody structure and function

Additional Information

• Proficiency in written and spoken English required

  
  

• Some travel may be required

This is an excellent opportunity to contribute to innovative protein engineering programs within a dynamic research environment while gaining valuable industry experience.

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